Not a great month
This month has been pretty awful (only the first one off progesterone). My period being a week and a half late didn't help. Even having an easy month at work didn't help, so i don't think stress is always a factor.
I have been pro-active and found some very good papers since i last researched PMS, ten years ago. These are definately worth reading:
The below link is a large study and well setup by sounds of it. It found that total oestrogen is the same between PMDD patients and controls but free E2 (oestrodiol) and %free E2 were lower and SHBG higher in PMDD subjects. This makes sense given oestrogen helps mood and oestrogen therapy successfully treated my PMDD for ten years.
http://jcem.endojournals.org/content/93/1/96.full
http://books.google.co.uk/books?id=00JbUu4lLsgC&pg=PA298&lpg=PA299&ots=nhLtAO3JF-&dq=serotonin+and+allopregnanolone&output=html_text
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098121/?report=classic
Magnesium is still successfully treating my insomnia. It still takes an hour to get to sleep if i go to bed too late but if i got to bed when sleepy/just after taking it, i tend to drop off quickly. I also sleep more deeply on it :)
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