Allopregnanolone

This article suggest a low dose of Prozac, only 2mg, can treat PMDD by increasing allopregnanolone levels. 
http://www.abc.net.au/catalyst/stories/3251902.htm

I did notice the biggest increase in mood swings/snappiness/aggression when i stopped taking the progesterone pessaries, a year after i stopped the oestrogen implant. So i think both oestrogen and progesterone, together, helped my PMDD. Oestrogen increases serotonin, leading to less depression. And progesterone is calming (it gets converted to allopregnanolone), leading to less violent mood swings. Progesterone is a tricky hormone for women to take tho, as it often has side-effects. Even tho it was natural progesterone i was taking, the delivery to the body is unnatural, as it's a big dose at once, in one area of the body (pessaries in my case). I did get irritable when i started taking progesterone but the sedating effect also calmed me and the irritability usually went away after a few days. I think it helped dampen my migraines too.