Allopregnanolone

This article suggest a low dose of Prozac, only 2mg, can treat PMDD by increasing allopregnanolone levels. 
http://www.abc.net.au/catalyst/stories/3251902.htm

I did notice the biggest increase in mood swings/snappiness/aggression when i stopped taking the progesterone pessaries, a year after i stopped the oestrogen implant. So i think both oestrogen and progesterone, together, helped my PMDD. Oestrogen increases serotonin, leading to less depression. And progesterone is calming (it gets converted to allopregnanolone), leading to less violent mood swings. Progesterone is a tricky hormone for women to take tho, as it often has side-effects. Even tho it was natural progesterone i was taking, the delivery to the body is unnatural, as it's a big dose at once, in one area of the body (pessaries in my case). I did get irritable when i started taking progesterone but the sedating effect also calmed me and the irritability usually went away after a few days. I think it helped dampen my migraines too.

Another shitty month!

Can really notice the difference now, being off the oestrogen implant :( Finding it so hard to concentrate for the entire 3 weeks of luteal phase, both on personal life and work. End up surfing the net instead of watching&relaxing tv in evenings, then realise it's ten pm and i've been faffing all evening and still feel wired. Feel angry that i'm going out, if have plans during the week because it feels so exhausting. Feel angry at wk colleagues all the time and cant really contain it when it gets to a week before period onwards :( Had massive fight with my manager and was anxious and tearful for a week afterwards. And my migraines have been horrendous. Had one every day for 3 weeks... then a 2 week gap, then yesterday (day 2) and today had a really awful one that made me almost throw up and hot and cold and weak and sick throughout body at times :( Have also gone home coz of migraines 3x in the last month or two and am a bit worried as my manager is probably monitoring everything i do since he keeps asking me what i'm doing everyday. So it's come at the worst time... I have had the extra stress of buying a flat to contend with but i think this is probably not the whole story :( The fight with manager didn't help either. So now i'm probably going to lose my job, as i find it hard to get focussed on anything.

I'm not sure if the testosterone implant caused the migraines, as they started the same month. They seem to be worst during period and in the luteal phase tho, but not in luteal phase which is weird. My cycle is messed up too, i used to have a 5 week cycle but now it's gone to 6.5 weeks and 6 weeks. That might be because oestrogen is still in my system and affecting the lining of my womb, i need to have a scan in January.